Chapter 8B Homework Questions

1. Explain the relationship between activation energy and free energy?

2. What is the relationship between activation energy and temperature?

3. What is the substrate?

4. What is “induced fit” with respect to an enzyme and its active site?

5. Draw graphs of how you would expect temperature and pH to effect the activity of an enzyme?

6. Malonate is a competitive inhibitor of the enzyme succinate dehydrogenase. How would malonate inhibit succinate dehydrogenase?

7. Describe feedback inhibition. What is a nonbiological example of feedback inhibition?

8. What is the difference between allosteric activation and inhibition?

9. Find the pathway for the biosynthesis of histidine. What compound in the pathway is most likely to be an allosteric inhibitor of histidine?